A dataset of low-carbon energy transition index for Chinese cities 2003–2019

Cities are at the heart of climate change mitigation as they account for over 70% of global carbon emissions. However, cities vary in their energy systems and socioeconomic capacities to transition to renewable energy. To address this heterogeneity, this study proposes an Energy Transition Index (ETI) specifically designed for cities, and applies it to track the progress of energy transition in Chinese cities. The city-level ETI framework is based on the national ETI developed by the World Economic Forum (WEF) and comprises two sub-indexes: the Energy System Performance sub-index, which evaluates the current status of cities’ energy systems in terms of energy transition, and the Transition Readiness sub-index, which assesses their socioeconomic capacity for future energy transition. The initial version of the dataset includes ETI and its sub-indexes for 282 Chinese cities from 2003 to 2019, with annual updates planned. The spatiotemporal data provided by the dataset facilitates research into the energy transition roadmap for different cities, which can help China achieve its energy transition goals

CO2 storage capacity estimation under geological uncertainty using 3-D geological modeling of unconventional reservoir rocks in Shahejie Formation, block Nv32, China

Underground CO2 storage is a promising technology for mitigating climate change. In this vein, the subsurface condition was inherited a lot of uncertainties that prevent the success of the CO2 storage project. Therefore, this study aims to build the 3D model under geological uncertainties for enhancing CO2 storage capacity in the Shahejie Formation (Es1), Nv32 block, China. The well logs, seismic data, and geological data were used for the construction of 3-D petrophysical models. The target study area model focused on four units (Es1 × 1, Es1 × 2, Es1 × 3, and Es1 × 4) in the Shahejie Formation. Well logs were utilized to predict petrophysical properties; the lithofacies indicated that the Shahejie Formation units are sandstone, shale, and limestone. Also, the petrophysical interpretation demonstrated that the $$Es1$$ E s 1 reservoir exhibited high percentage porosity, permeability, and medium to high net-to-gross ratios. The static model showed that there are lateral heterogeneities in the reservoir properties and lithofacies; optimal reservoir rocks exist in Es1 × 4, Es1 × 3, and Es1 × 2 units. Moreover, the pore volume of the Es1 unit was estimated from petrophysical property models, ranging between 0.554369 and 10.03771 × 106 sm3, with a total volumetric value of 20.0819 × 106 sm3 for the four reservoir units. Then, the 100–400 realizations were generated for the pore volume uncertainties assessment. In consequence, 200 realizations were determined as an optimal solution for capturing geological uncertainties. The estimation of CO2 storage capacity in the Es1 formation ranged from 15.6 to 207.9 × 109 t. This result suggests the potential of CO2 geological storage in the Shahejie Formation, China

Detection of genome-wide structural variations in the Shanghai Holstein cattle population using next-generation sequencing

Objective The Shanghai Holstein cattle breed is susceptible to severe mastitis and other diseases due to the hot weather and long-term humidity in Shanghai, which is the main distribution centre for providing Holstein semen to various farms throughout China. Our objective was to determine the genetic mechanisms influencing economically important traits, especially diseases that have huge impact on the yield and quality of milk as well as reproduction. Methods In our study, we detected the structural variations of 1,092 Shanghai Holstein cows by using next-generation sequencing. We used the DELLY software to identify deletions and insertions, cn.MOPS to identify copy-number variants (CNVs). Furthermore, we annotated these structural variations using different bioinformatics tools, such as gene ontology, cattle quantitative trait locus (QTL) database and ingenuity pathway analysis (IPA). Results The average number of high-quality reads was 3,046,279. After filtering, a total of 16,831 deletions, 12,735 insertions and 490 CNVs were identified. The annotation results showed that these mapped genes were significantly enriched for specific biological functions, such as disease and reproduction. In addition, the enrichment results based on the cattle QTL database showed that the number of variants related to milk and reproduction was higher than the number of variants related to other traits. IPA core analysis found that the structural variations were related to reproduction, lipid metabolism, and inflammation. According to the functional analysis, structural variations were important factors affecting the variation of different traits in Shanghai Holstein cattle. Our results provide meaningful information about structural variations, which may be useful in future assessments of the associations between variations and important phenotypes in Shanghai Holstein cattle. Conclusion Structural variations identified in this study were extremely different from those of previous studies. Many structural variations were found to be associated with mastitis and reproductive system diseases; these results are in accordance with the characteristics of the environment that Shanghai Holstein cattle experience

CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse

The X‐linked genetic bleeding disorder caused by deficiency of coagulator factor IX, hemophilia B, is a disease ideally suited for gene therapy with genome editing technology. Here, we identify a family with hemophilia B carrying a novel mutation, Y371D, in the human F9 gene. The CRISPR/Cas9 system was used to generate distinct genetically modified mouse models and confirmed that the novel Y371D mutation resulted in a more severe hemophilia B phenotype than the previously identified Y371S mutation. To develop therapeutic strategies targeting this mutation, we subsequently compared naked DNA constructs versus adenoviral vectors to deliver Cas9 components targeting the F9 Y371D mutation in adult mice. After treatment, hemophilia B mice receiving naked DNA constructs exhibited correction of over 0.56% of F9 alleles in hepatocytes, which was sufficient to restore hemostasis. In contrast, the adenoviral delivery system resulted in a higher corrective efficiency but no therapeutic effects due to severe hepatic toxicity. Our studies suggest that CRISPR/Cas‐mediated in situ genome editing could be a feasible therapeutic strategy for human hereditary diseases, although an efficient and clinically relevant delivery system is required for further clinical studies

Screening and identification of potential bioactive constituents in a new herbal prescription seaweed complex preparation

Background: Seaweed Complex Preparation (SCP) is a clinical traditional Chinese medicine preparation composed of seven traditional Chinese herbs, and has been used for treatment of lung cancer, liver cancer and digestive cancer.Materials and Methods: In this study, the potential bioactive constituents of SCP were isolated and identified by chromatographic and spectroscopic methods. The immunomodulatory and DPPH radical scavenging activities of the constituents were also evaluated in vitro.Results: Forty-three compounds were isolated from the EtOAc and n BuOH fractions of the decocted extracts. More than 10 structural types of chemical constituents were found, including flavonoid glycosides, flavonoids, phenolic acid compounds, lignans, iridoid glycosides, and polysaccharides mainly composed of galactose and glucose. Flavonoid glycosides exhibited potential immunomodulatory by promoting splenic lymphocyte proliferation and stimulating the secretion of cytokines IL 2 and IFN-γ, as well as free radical (DPPH) scavenging activities. Caffeic acid derivatives showed remarkable free radical (DPPH) scavenging activity, while polysaccharides also displayed immunological enhancement effects.Conclusion: Four molecular communities, flavonoid glycosides, flavonoids, phenolic compounds and polysaccharides, might be the potential bioactive components of SCP. Synergism of these four molecular communities in SCP may endue the anticancer properties and reflect the feature of multi-components and multi targets of traditional Chinese medicine formula.Keywords: Traditional Chinese Medicine Preparation, Seaweed Complex Preparation, Bioactive constituents, Free radical scavenging; Immunomodulator

The Coupled Thermal-Structural Resonance Reliability Sensitivity Analysis of Gear-Rotor System with Random Parameters

The resonance of the gear-rotor system will produce a large number of responses that do not exceed the threshold value, resulting in structural fatigue failure and transmission failure, affecting its life and reliability. It is particularly critical to consider the temperature rise under high-speed and heavy-load conditions. Therefore, the research will take the main drive gear-rotor system of a certain type of aeroengine accessory gearbox as the research object, consider the influence of the temperature field on the natural frequency of the gear-rotor system, and take the difference between the natural frequency of the gear-rotor system and the excitation frequency (gear meshing frequency) as the performance function. The PC-Kriging and adaptive design of experimental strategies are applied to the thermal-structural coupling parametric model to analyze the resonance reliability and sensitivity of the gear-rotor system. For complex mechanical mechanisms, the method has better accuracy than other surrogate models and greatly saves the time of finite element simulation in reliability analysis. The results show that the natural frequency of a gear rotor decreases with an increase in temperature, and the natural frequency of different orders varies with the change in temperature. The influence of the sensitivity of different random parameters on the resonance reliability of the gear-rotor system is obtained. Reliability research on resonance failure of high-speed and heavy-load aviation gear-rotor systems considering random parameters under a temperature rise field has important practical engineering application value and scientific research significance

Corona delle nobili et virtuose donne [...] : [estampe, livre de modèles]

Ancien possesseur : Davillier, Jean-Charles (1823-1883). Ancien possesseu

Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China.

The chemical composition, anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita (MEO) grown in China were investigated. Using GC-MS analysis, the chemical composition of MEO was characterized, showing that it was mainly composed of menthol, menthone and menthy acetate. MEO exhibited potent anti-inflammatory activities in a croton oil-induced mouse ear edema model. It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. The cytotoxic effect was assessed against four human cancer cells. MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively. In addition, MEO had moderate antioxidant activity. The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources